Adverse reactions to drugs and their physico-chemical properties

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Adverse reactions to drugs and their physico-chemical properties.

Introduction There is now much information associating desirable and undesirable actions with chemical structure and constitution and physical properties. Hundreds of thousands of natural and synthesized compounds have been subjected to bacterial, animal and human toxicological studies and the information has been stored by computer and can be retrieved as an aid to literature search when embar...

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Adverse ocular reactions to drugs.

Drugs acting on various parts of the body may also affect the eye insidiously. Increased awareness of such drug toxicity by the prescribing doctor should encourage him to consider effects on the cornea, lens, retina, optic nerve and elsewhere when checking the patient's progress. The following review concerns adverse ocular effects of systemic drug administration.

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Monitoring adverse reactions to drugs.

If you're thinking seriously of a short time in a developing country, you would probably enjoy this sort of job. Patients get better, and seem to enjoy doing so, so it is immensely rewarding in terms of job satisfaction. There is excellent clinical experience to be had, and the chance to become clinically more self-reliant. The medicine, however, is probably relatively elementary, and facilitie...

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Adverse cutaneous reactions to drugs.

Drug eruptions are probably the most frequent of all manifestations of drug sensitivity. They occur in about 2% of treatment courses and are commoner in women, the elderly and in patients with the acquired immunodeficiency syndrome (AIDS), especially from sulphonamides such as in co-trimoxazole1. Drugs most often incriminated are listed in Table 1. The prevalence of a history of penicillin alle...

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extraction and acetylation of purified trypsin from bovin pancreas and study of some its physico-chemical properties

آنزیم تریپسین در شرایط قلیایی ناپایدار می باشد .و فعالیت پروتئولیتیکی تریپسین منجربه خود هضمی آن در جایگاههای خاصی می گردد. بنابر این آنزیمی با ناپایداری بالا محسوب میگردد. در سالهای اخیر موفق شدند که با ایجاد تغیرات شیمیایی با اضافه کردن فلزات خاص ، کلسیم و یا عمل استیلاسیون منجر به افزایش پایداری آنزیم تریپسین گردند. مطالعات در حال حاضر نشان می دهد که تریپسین استیله شده فعالیت آنزیمی خود را ...

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ژورنال

عنوان ژورنال: Postgraduate Medical Journal

سال: 1981

ISSN: 0032-5473

DOI: 10.1136/pgmj.57.673.679